Spatiotemporally controlled nano-sized third harmonic generation agents

Nano-antenna-assisted harmonic generation

We report on low-order harmonic generation utilising the plasmonic field enhancement in arrays of rodtype gold optical antennae. Furthermore, we examine their suitability to support high-order harmonic generation (HHG). The low-order harmonics are used as a tool to investigate the nonlinear properties of the antennae. Particular attention is paid to the thermal properties, which become signific...

Nano-sized Drug Delivery Platforms for Taxane Antineoplastic Agents

The prototype taxane antineoplastic agent paclitaxel, was first isolated from the bark of the Western yew tree in 1971. It and its congener, the semisynthetic derivative docetaxel, display unique pharmacodynamics as mitotic spindle poisons, differing from the vinca alkaloids and colchicine derivatives in that they bind to a distinct site on β-tubulin and promote rather than inhibit microtubule ...

Simultaneous four-photon luminescence, third-harmonic generation, and second-harmonic generation microscopy of GaN.

We demonstrate what is to our knowledge the first example of four-photon luminescence microscopy in GaN and apply it to quality mapping of bulk GaN. The simultaneously acquired second- and third-harmonic generation can be used to map the distribution of the piezoelectric field and the band-tail state density, respectively. Through spectrum- and power-dependent studies, the fourth power dependen...

Spatiotemporally controlled single cell sonoporation.

This paper presents unique approaches to enable control and quantification of ultrasound-mediated cell membrane disruption, or sonoporation, at the single-cell level. Ultrasound excitation of microbubbles that were targeted to the plasma membrane of HEK-293 cells generated spatially and temporally controlled membrane disruption with high repeatability. Using whole-cell patch clamp recording com...

Continuous third harmonic generation in a terahertz driven modulated nanowire